FAQ for genomic selection

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Pre-selection of markers for genomic selection

BACKGROUND Accurate prediction of genomic breeding values (GEBVs) requires numerous markers. However, predictive accuracy can be enhanced by excluding markers with no effects or with inconsistent effects among crosses that can adversely affect the prediction of GEBVs. METHODS We present three different approaches for pre-selecting markers prior to predicting GEBVs using four different BLUP me...

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Improved Lasso for genomic selection.

Empirical experience with genomic selection in dairy cattle suggests that the distribution of the effects of single nucleotide polymorphisms (SNPs) might be far from normality for some traits. An alternative, avoiding the use of arbitrary prior information, is the Bayesian Lasso (BL). Regular BL uses a common variance parameter for residual and SNP effects (BL1Var). We propose here a BL with di...

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Genomic selection.

Genomic selection is a form of marker-assisted selection in which genetic markers covering the whole genome are used so that all quantitative trait loci (QTL) are in linkage disequilibrium with at least one marker. This approach has become feasible thanks to the large number of single nucleotide polymorphisms (SNP) discovered by genome sequencing and new methods to efficiently genotype large nu...

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GENOMIC SELECTION Genomic Selection in Multi-environment Crop Trials

Genomic selection in crop breeding introduces modeling challenges not found in animal studies. These include the need to accommodate replicate plants for each line, consider spatial variation in field trials, address line by environment interactions, and capture nonadditive effects. Here, we propose a flexible single-stage genomic selection approach that resolves these issues. Our linear mixed ...

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ژورنال

عنوان ژورنال: Journal of Animal Breeding and Genetics

سال: 2011

ISSN: 0931-2668

DOI: 10.1111/j.1439-0388.2011.00944.x